A woman treated with ovarian stimulation for ART, in which at least two of the following features are present: (1) Advanced maternal age (R40 years); (2) A previous poor ovarian response (%3 oocytes with a conventional stimulation protocol aimed at obtaining more than three oocytes); and, (3) An abnormal ovarian reserve test (i.e. antral follicle count 5–7 follicles or anti-Mullerian hormone 0.5–1.1 ng/ml (Bologna criteria); or other reference values obtained from a standardized reference population.)

A condition in which fewer than four follicles and/or oocytes are developed/obtained following ovarian stimulation with the intention of obtaining more follicles and oocytes.

An embryo at a stage of development beyond attachment to the endometrium to eight completed weeks after fertilization, which is equivalent to 10 weeks of gestational age.

A live birth or stillbirth that takes place after 42 completed weeks of gestational age.

A process utilizing gametes and/or embryos from a deceased person or persons with the intention of producing offspring.

An embryo at a stage of development beginning

A state of reproduction beginning with implantation of an embryo in a woman and ending with the complete expulsion and/or extraction of all products of implantation.

The outcome of any pregnancy that does not result in at least one live birth. When reporting pregnancy loss, the estimated gestational age at the end of pregnancy should be recorded.

A pregnancy documented by a positive human chorionic gonadotropin (hCG) test without visualization of pregnancy by ultrasound. This condition exists only after circulating hCG concentration is compatible with ultrasound visualization of a gestational sac.

These terms have now been replaced by preimplantation genetic testing PGT. (See term PGT and its definitions.)

A test performed to analyze the DNA from oocytes (polar bodies) or embryos (cleavage stage or blastocyst) for HLA-typing or for determining genetic abnormalities. These include: PGT for aneuploidies (PGT-A); PGT for monogenic/single gene defects (PGT-M); and PGT for chromosomal structural rearrangements (PGT-SR).

A condition in which semen is released sooner than desired.

A condition characterized by hypergonadotropic hypogonadism in women younger than age 40 years (also known as premature or primary ovarian failure). It includes women with premature menopause.

A birth that takes place after 22 weeks and before 37 completed weeks of gestational age.

A condition in which a person has never delivered a live child, or has never been a legal or societallyrecognized parent to a child.

A woman who has never been diagnosed with a clinical pregnancy and meets the criteria of being classified as having infertility.

A condition in a person with a child wish, who has never delivered a live child, or has never been a legal or societally-recognized parent to a child. A major cause of primary involuntary childlessness is infertility.

A man who has never initiated a clinical pregnancy and meets the criteria of being classified as infertile.

Transfer of the pronuclei from a patient’s zygote to an enucleated donated zygote.

A round structure in the oocyte surrounded by a membrane containing chromatin. Normally, two pronuclei are seen after fertilization, each containing a haploid set of chromosomes, one set from the oocyte and one from the sperm, before zygote formation.